Riferimento farmaci
Vonoprazan
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for gerd.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: gerd
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 20 mg, 10 mg
- Interazioni note
- 42 (Maggiore: 6 · Moderata: 26 · Minore: 10)
- Nomi commerciali
- 10
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Vonoprazan suppresses basal and stimulated gastric acid secretion by inhibiting the H+,K+-ATPase enzyme system in parietal cells in a potassium-competitive manner. It binds to active pumps noncovalently and reversibly and does not require activation by acid.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Healing of erosive esophagitis: 20 mg orally once daily for 8 weeks
Come si assume di solito
Proton pump inhibitors are usually taken by mouth once a day, often before a meal, for a course whose length depends on the reason for treatment.
Gravidanza e allattamento
- Gravidanza
- Unknown No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists.
- Allattamento
- Unknown Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
Effetti indesiderati segnalati
- Gastritis
- Diarrhea
- Abdominal pain
- Nausea
- Abdominal distension
- Dyspepsia
Controindicazioni
- Known hypersensitivity to vonoprazan or any component of the product (reactions have included anaphylactic shock)
- Concomitant use with rilpivirine-containing products
Chi deve prestare attenzione
- Symptomatic response does not preclude gastric malignancy; consider further follow-up and testing, and endoscopy in older patients.
- Acute tubulointerstitial nephritis: discontinue and evaluate if suspected.
- May increase risk of Clostridioides difficile-associated diarrhea; use the shortest duration appropriate.
People taking proton pump inhibitors for a long time should have the need for treatment reviewed, because long-term use is linked to low magnesium, vitamin B12 deficiency, bone fractures and gut infections. Tell your pharmacist about all other medicines, since some interact.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (42)
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
- Armodafinil + Vonoprazan Moderate
- Bosentan + Vonoprazan Moderate
- Carbonyl iron + Vonoprazan Moderate
- Cilostazol + Vonoprazan Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Vonoprazan used for?
Vonoprazan is a medicine in the class gastrointestinal tract. It is used for GERD, Heartburn, Helicobacter pylori bacteria.
What side effects have been reported with Vonoprazan?
Gastritis, Diarrhea, Abdominal pain, Nausea, Abdominal distension, Dyspepsia.
Can Vonoprazan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate and well-controlled studies in pregnant women; available data are insufficient to evaluate drug-associated risk. A pregnancy exposure registry exists. Breastfeeding: Unknown. Vonoprazan is present in breast milk at less than 0.03% of the maternal dose. No data on effects on the breastfed child. Animal liver injury occurred in offspring. Weigh benefits of breastfeeding against maternal need.
What does Vonoprazan interact with?
MediHelp lists 42 known interactions for Vonoprazan. Major: 6 · Moderate: 26 · Minor: 10. The most serious include Amobarbital, Apalutamide, Atazanavir.
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