Riferimento farmaci
Vorinostat
Vorinostat is a medicine in the class oncology. It is used for lymphoma.
- Classe del farmaco: Oncology
- Indicato per: lymphoma
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 100 mg
- Interazioni note
- 109 (Controindicata: 1 · Maggiore: 32 · Moderata: 74 · Minore: 2)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Inhibits histone deacetylases HDAC1, HDAC2, HDAC3 (Class I) and HDAC6 (Class II), causing accumulation of acetylated histones, open chromatin and transcriptional activation, and in vitro cell cycle arrest and/or apoptosis of some transformed cells.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Cutaneous T-cell lymphoma (cutaneous manifestations, after two systemic therapies): 400 mg orally once daily with food; continue as long as no progressive disease or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months).
- Allattamento
- Unsafe No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
Effetti indesiderati segnalati
- Diarrhea
- Fatigue
- Nausea
- Dysgeusia
- Thrombocytopenia
- Anorexia
Chi deve prestare attenzione
- Thromboembolism: pulmonary embolism occurred in 5% (4/86) and DVT reported; monitor for signs and symptoms.
- Myelosuppression: dose-related thrombocytopenia and anemia; monitor blood counts every 2 weeks for the first 2 months, then monthly.
- Gastrointestinal toxicity: nausea, vomiting, diarrhea may need antiemetics, antidiarrheals and fluid/electrolyte replacement; control pre-existing symptoms before starting.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (109)
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
- Clarithromycin + Vorinostat Major
- Clozapine + Vorinostat Major
- Deferiprone + Vorinostat Major
- Dronedarone + Vorinostat Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Vorinostat used for?
Vorinostat is a medicine in the class oncology. It is used for Lymphoma.
What side effects have been reported with Vorinostat?
Diarrhea, Fatigue, Nausea, Dysgeusia, Thrombocytopenia, Anorexia.
Can Vorinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months). Breastfeeding: Unsafe. No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
What does Vorinostat interact with?
MediHelp lists 109 known interactions for Vorinostat. Contraindicated: 1 · Major: 32 · Moderate: 74 · Minor: 2. The most serious include Thioridazine, Amiodarone, Amisulpride.
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