Interazioni tra farmaci
Thioridazine + Vorinostat
Gravità: Controindicata
Thioridazine and Vorinostat: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Vorinostat has been associated with QT prolongation, and thioridazine markedly prolongs QTc. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances common in oncology patients.
Cosa significa questa interazione in parole semplici
Thioridazine and Vorinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Thioridazine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Perché avviene
Additive effects on cardiac repolarization leading to QT prolongation.
Cosa fare
Avoid combining; use an alternative antipsychotic. If vorinostat is essential, correct potassium and magnesium and do not use thioridazine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Altre interazioni di Vorinostat
- Amiodarone + Vorinostat Maggiore
- Amisulpride + Vorinostat Maggiore
- Anagrelide + Vorinostat Maggiore
- Asenapine + Vorinostat Maggiore
- Chlorpromazine + Vorinostat Maggiore
- Clarithromycin + Vorinostat Maggiore
Domande frequenti
Can I take Thioridazine with Vorinostat?
MediHelp rates the interaction as contraindicated. Thioridazine and Vorinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vorinostat has been associated with QT prolongation, and thioridazine markedly prolongs QTc. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances common in oncology patients.
How serious is the interaction between Thioridazine and Vorinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use an alternative antipsychotic. If vorinostat is essential, correct potassium and magnesium and do not use thioridazine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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