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Interazioni tra farmaci

Aceclofenac + Mesalamine

Gravità: Moderata

Aceclofenac and Mesalamine: moderate interaction.

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Sintesi

Mesalamine can cause interstitial nephritis, and NSAIDs reduce renal prostaglandin-mediated perfusion. Together they may raise the risk of kidney injury.

Cosa significa questa interazione in parole semplici

Aceclofenac and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aceclofenac belongs to Musculoskeletal; Mesalamine belongs to Gastrointestinal Tract.

Livello di evidenza: Moderate

Perché avviene

Additive nephrotoxicity from mesalamine interstitial nephritis and NSAID-induced renal hemodynamic effects.

Cosa fare

Monitor serum creatinine at baseline and periodically; avoid NSAIDs where possible in patients with renal impairment.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Aceclofenac with Mesalamine?

MediHelp rates the interaction as moderate. Aceclofenac and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can cause interstitial nephritis, and NSAIDs reduce renal prostaglandin-mediated perfusion. Together they may raise the risk of kidney injury.

How serious is the interaction between Aceclofenac and Mesalamine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine at baseline and periodically; avoid NSAIDs where possible in patients with renal impairment.

What other medicines interact with Mesalamine?

MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Acemetacin. The full list is on the Mesalamine page.

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