Riferimento farmaci
Mesalamine
Mesalamine is a medicine in the class gastrointestinal tract. It is used for ulcerative colitis.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: ulcerative colitis
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Noto anche come
- Mesalazine
- Forme farmaceutiche comuni
- compressa, capsula, supposta, bustina, sospensione orale
- Dosaggi comuni
- 1 g, 500 mg, 2 g
- Interazioni note
- 125 (Maggiore: 2 · Moderata: 48 · Minore: 75)
- Nomi commerciali
- 50
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Anti-inflammatory agent; mesalamine (5-aminosalicylic acid) is the active component of sulfasalazine, but specific MOA is unknown; probably inhibits prostaglandin and leukotriene synthesis and release in colon.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Ulcerative Colitis (Pentasa): 1 g/day orally four times daily for up to 8 weeks.
Gravidanza e allattamento
- Gravidanza
- Safe Meta-analyses and cohort studies show no reliable link with birth defects, miscarriage or poor outcomes; no harm in animals. Active ulcerative colitis itself raises pregnancy risks, so continue treatment.
- Allattamento
- Safe Passes into milk in small amounts (mesalamine 0.1% or less of the maternal dose; more of an inactive metabolite). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea.
Effetti indesiderati segnalati
- Headache
- Abdominal pain
- Flatulence
- GI discomfort
Controindicazioni
- Hypersensitivity to mesalamine or salicylates
- Breastfeeding
- Rectal suspension: Hypersensitivity to salicylates, aminosalicylates or to any ingredients in the suppository vehicle
Chi deve prestare attenzione
- Oligospermia has been reported in males.
- ensure adequate fluid intake during treatment; evaluate renal function prior to initiation of therapy and periodically while on therapy.
- advise patients to avoid sun exposure, wear protective clothing, and use a broad-spectrum sunscreen when outdoors.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (125)
- Measles mumps rubella and varicella vaccine live + Mesalamine Major
- Mesalamine + Varicella virus vaccine live Major
- Aceclofenac + Mesalamine Moderate
- Acemetacin + Mesalamine Moderate
- Acetylsalicylic acid + Mesalamine Moderate
- Aspirin + Mesalamine Moderate
- Aspirin / citric acid / sodium bicarbonate + Mesalamine Moderate
- Aspirin rectal + Mesalamine Moderate
- Azathioprine + Mesalamine Moderate
- Balsalazide + Mesalamine Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Mesalamine used for?
Mesalamine is a medicine in the class gastrointestinal tract. It is used for Ulcerative colitis.
What side effects have been reported with Mesalamine?
Headache, Abdominal pain, Flatulence, GI discomfort.
Can Mesalamine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Meta-analyses and cohort studies show no reliable link with birth defects, miscarriage or poor outcomes; no harm in animals. Active ulcerative colitis itself raises pregnancy risks, so continue treatment. Breastfeeding: Safe. Passes into milk in small amounts (mesalamine 0.1% or less of the maternal dose; more of an inactive metabolite). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea.
What does Mesalamine interact with?
MediHelp lists 125 known interactions for Mesalamine. Major: 2 · Moderate: 48 · Minor: 75. The most serious include Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac.
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