Interazioni tra farmaci
Acetylsalicylic acid + Lesinurad
Gravità: Moderata
Acetylsalicylic acid and Lesinurad: moderate interaction.
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Sintesi
High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
Cosa significa questa interazione in parole semplici
Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
Perché avviene
Salicylates interfere with renal urate handling at the tubular level, and this may counteract the uricosuric effect, though the exact mechanism is not firmly established.
Cosa fare
Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Controindicata
- Acetylsalicylic acid + Ketorolac intranasal Controindicata
- Abciximab + Acetylsalicylic acid Maggiore
- Acemetacin + Acetylsalicylic acid Maggiore
- Acetazolamide + Acetylsalicylic acid Maggiore
- Acetylsalicylic acid + Alteplase Maggiore
Altre interazioni di Lesinurad
- Lesinurad + Norethisterone Maggiore
- Amiodarone + Lesinurad Moderata
- Apalutamide + Lesinurad Moderata
- Desogestrel-ethinyl estradiol + Lesinurad Moderata
- Dienogest / estradiol valerate + Lesinurad Moderata
- Ethinyl estradiol-drospirenone + Lesinurad Moderata
Domande frequenti
Can I take Acetylsalicylic acid with Lesinurad?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
How serious is the interaction between Acetylsalicylic acid and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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