Riferimento farmaci
Lesinurad
Lesinurad is a medicine in the class genitourinary.
- Classe del farmaco: Genitourinary
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Genitourinary
- Interazioni note
- 58 (Maggiore: 1 · Moderata: 23 · Minore: 34)
- Nomi commerciali
- 1
Come agisce
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hyperuricemia: 200 mg PO qDay in combination with a xanthine oxidase inhibitor (ie, allopurinol or febuxostat)
Gravidanza e allattamento
- Gravidanza
- Unknown Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait.
- Allattamento
- Unknown Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
Effetti indesiderati segnalati
- Headache
- Influenza
- Renal failure
- GERD
- Increased creatinine
Controindicazioni
- Severe renal impairment (estimated CrCl <30 mL/min), end-stage renal disease, kidney transplant recipients, or patients on dialysis
- Tumor lysis syndrome or Lesch-Nyhan syndrome
Chi deve prestare attenzione
- Contraindicated in Tumor lysis syndrome or Lesch-Nyhan syndrome.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (58)
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
- Ethinyl estradiol-drospirenone + Lesinurad Moderate
- Ethinyl estradiol-levonorgestrel + Lesinurad Moderate
- Ethinylestradiol + Lesinurad Moderate
- Etonogestrel + Lesinurad Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Lesinurad used for?
Lesinurad is a medicine in the class genitourinary.
What side effects have been reported with Lesinurad?
Headache, Influenza, Renal failure, GERD, Increased creatinine.
Can Lesinurad be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait. Breastfeeding: Unknown. Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
What does Lesinurad interact with?
MediHelp lists 58 known interactions for Lesinurad. Major: 1 · Moderate: 23 · Minor: 34. The most serious include Norethisterone, Acetylsalicylic acid, Amiodarone.
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