Interazioni tra farmaci
Adenovirus types 4 and 7 live + Cyclophosphamide
Gravità: Maggiore
Adenovirus types 4 and 7 live and Cyclophosphamide: major interaction.
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Sintesi
Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
Cosa significa questa interazione in parole semplici
Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cytotoxic immunosuppression impairs vaccine immune response and permits replication of the live attenuated virus.
Cosa fare
Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cyclophosphamide
- Belatacept + Cyclophosphamide Maggiore
- Bendamustine + Cyclophosphamide Maggiore
- Busulfan + Cyclophosphamide Maggiore
- Carmustine + Cyclophosphamide Maggiore
- Cyclophosphamide + Deferiprone Maggiore
- Cyclophosphamide + Dengue vaccine Maggiore
Domande frequenti
Can I take Adenovirus types 4 and 7 live with Cyclophosphamide?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Belatacept, Bendamustine, Busulfan. The full list is on the Cyclophosphamide page.
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