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Interazioni tra farmaci

Cyclophosphamide + Deferiprone

Gravità: Maggiore

Cyclophosphamide and Deferiprone: major interaction.

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Sintesi

Deferiprone can cause neutropenia and agranulocytosis, and cyclophosphamide is itself myelosuppressive. Combined use increases the risk of severe, potentially fatal infections.

Cosa significa questa interazione in parole semplici

Cyclophosphamide and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclophosphamide belongs to Oncology; Deferiprone belongs to Miscellaneous.

Livello di evidenza: Moderate

Perché avviene

Additive bone marrow suppression with pharmacodynamic synergy on neutrophil depletion.

Cosa fare

Avoid the combination if possible. If necessary, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia develops.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cyclophosphamide with Deferiprone?

MediHelp rates the interaction as major. Cyclophosphamide and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and cyclophosphamide is itself myelosuppressive. Combined use increases the risk of severe, potentially fatal infections.

How serious is the interaction between Cyclophosphamide and Deferiprone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia develops.

What other medicines interact with Cyclophosphamide?

MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.

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