Interazioni tra farmaci
Adenovirus types 4 and 7 live + Irinotecan
Gravità: Maggiore
Adenovirus types 4 and 7 live and Irinotecan: major interaction.
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Sintesi
Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
Cosa significa questa interazione in parole semplici
Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cytotoxic immunosuppression impairs the immune response to live attenuated virus, allowing uncontrolled replication and reducing vaccine efficacy.
Cosa fare
Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Irinotecan
- Clozapine + Irinotecan Controindicata
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- Apalutamide + Irinotecan Maggiore
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- Clarithromycin + Irinotecan Maggiore
Domande frequenti
Can I take Adenovirus types 4 and 7 live with Irinotecan?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
How serious is the interaction between Adenovirus types 4 and 7 live and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Apalutamide. The full list is on the Irinotecan page.
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