Interazioni tra farmaci
Alfentanil + Diphenoxylate-atropine
Gravità: Maggiore
Alfentanil and Diphenoxylate-atropine: major interaction.
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Sintesi
Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
Cosa significa questa interazione in parole semplici
Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive opioid-mediated CNS and respiratory depression.
Cosa fare
Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Controindicata
- Diphenoxylate-atropine + Phenelzine Controindicata
- Diphenoxylate-atropine + Tranylcypromine Controindicata
- Alvimopan + Diphenoxylate-atropine Maggiore
- Amitriptyline + Diphenoxylate-atropine Maggiore
- Amobarbital + Diphenoxylate-atropine Maggiore
Domande frequenti
Can I take Alfentanil with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Alfentanil and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diphenoxylate is an opioid, and together with alfentanil it can increase sedation and respiratory depression. Risk is higher at high diphenoxylate doses or in children and those with hepatic impairment.
How serious is the interaction between Alfentanil and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation level during alfentanil use and reduce the alfentanil dose as needed. Hold diphenoxylate-atropine where possible around procedures.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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