Interazioni tra farmaci
Alvimopan + Diphenoxylate-atropine
Gravità: Maggiore
Alvimopan and Diphenoxylate-atropine: major interaction.
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Sintesi
Alvimopan is a peripherally acting mu-opioid antagonist, and diphenoxylate is an opioid. Opioid-exposed patients may be more sensitive to alvimopan and can develop abdominal pain, nausea, vomiting and diarrhea, while antidiarrheal efficacy may be reduced.
Cosa significa questa interazione in parole semplici
Alvimopan and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Competitive antagonism of peripheral mu-opioid receptors by alvimopan opposes diphenoxylate's gut effects.
Cosa fare
Avoid alvimopan in patients who have been taking opioids, including diphenoxylate, for a prolonged period before surgery. Use alternative management for diarrhea and postoperative ileus if appropriate.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Controindicata
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- Alfentanil + Diphenoxylate-atropine Maggiore
- Amitriptyline + Diphenoxylate-atropine Maggiore
- Amobarbital + Diphenoxylate-atropine Maggiore
Domande frequenti
Can I take Alvimopan with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Alvimopan and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Alvimopan is a peripherally acting mu-opioid antagonist, and diphenoxylate is an opioid. Opioid-exposed patients may be more sensitive to alvimopan and can develop abdominal pain, nausea, vomiting and diarrhea, while antidiarrheal efficacy may be reduced.
How serious is the interaction between Alvimopan and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid alvimopan in patients who have been taking opioids, including diphenoxylate, for a prolonged period before surgery. Use alternative management for diarrhea and postoperative ileus if appropriate.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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