Interazioni tra farmaci
Allopurinol + Ampicillin
Gravità: Moderata
Allopurinol and Ampicillin: moderate interaction.
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Sintesi
Patients taking allopurinol together with ampicillin have a higher reported frequency of skin rash than those taking either drug alone. The rash is generally mild and may be hard to tell apart from allopurinol hypersensitivity, which can occasionally be serious.
Cosa significa questa interazione in parole semplici
Allopurinol and Ampicillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Ampicillin belongs to Anti Bacterial.
Perché avviene
The mechanism is not established; an additive or synergistic hypersensitivity-type reaction has been proposed.
Cosa fare
Counsel the patient to report any rash promptly and evaluate it carefully for allopurinol hypersensitivity. If a rash appears, stop allopurinol and consider an alternative antibiotic.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Allopurinol
- Allopurinol + Azathioprine Maggiore
- Allopurinol + Didanosine Maggiore
- Allopurinol + Mercaptopurine Maggiore
- Allopurinol + Pexidartinib Maggiore
- Allopurinol + Amlodipine-benazepril Moderata
- Allopurinol + Amlodipine-perindopril Moderata
Altre interazioni di Ampicillin
- Ampicillin + Bcg vaccine live Moderata
- Ampicillin + Chloramphenicol Moderata
- Ampicillin + Chloroquine Moderata
- Ampicillin + Cholera vaccine Moderata
- Ampicillin + Demeclocycline Moderata
- Ampicillin + Eravacycline Moderata
Domande frequenti
Can I take Allopurinol with Ampicillin?
MediHelp rates the interaction as moderate. Allopurinol and Ampicillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking allopurinol together with ampicillin have a higher reported frequency of skin rash than those taking either drug alone. The rash is generally mild and may be hard to tell apart from allopurinol hypersensitivity, which can occasionally be serious.
How serious is the interaction between Allopurinol and Ampicillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report any rash promptly and evaluate it carefully for allopurinol hypersensitivity. If a rash appears, stop allopurinol and consider an alternative antibiotic.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
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