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Interazioni tra farmaci

Ampicillin + Chloramphenicol

Gravità: Moderata

Ampicillin and Chloramphenicol: moderate interaction.

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Sintesi

Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.

Cosa significa questa interazione in parole semplici

Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ampicillin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Pharmacodynamic antagonism: inhibition of bacterial protein synthesis and growth reduces penicillin killing.

Cosa fare

Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Ampicillin with Chloramphenicol?

MediHelp rates the interaction as moderate. Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.

How serious is the interaction between Ampicillin and Chloramphenicol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.

What other medicines interact with Ampicillin?

MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloroquine. The full list is on the Ampicillin page.

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