Interazioni tra farmaci
Aluminum hydroxide + Rilpivirine
Gravità: Maggiore
Aluminum hydroxide and Rilpivirine: major interaction.
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Sintesi
Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
Cosa significa questa interazione in parole semplici
Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aluminum hydroxide belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Perché avviene
Elevated gastric pH reduces rilpivirine solubility and oral absorption.
Cosa fare
Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Aluminum hydroxide
- Aluminum hydroxide + Ciprofloxacin Maggiore
- Aluminum hydroxide + Deferasirox Maggiore
- Aluminum hydroxide + Dolutegravir Maggiore
- Aluminum hydroxide + Raltegravir Maggiore
- Aluminum hydroxide + Vitamin d Maggiore
- Acalabrutinib + Aluminum hydroxide Moderata
Altre interazioni di Rilpivirine
- Carbamazepine + Rilpivirine Controindicata
- Dexamethasone + Rilpivirine Controindicata
- Dexlansoprazole + Rilpivirine Controindicata
- Efavirenz + Rilpivirine Controindicata
- Eslicarbazepine + Rilpivirine Controindicata
- Esomeprazole + Rilpivirine Controindicata
Domande frequenti
Can I take Aluminum hydroxide with Rilpivirine?
MediHelp rates the interaction as major. Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
How serious is the interaction between Aluminum hydroxide and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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