Interazioni tra farmaci
Amisulpride + Lithium
Gravità: Maggiore
Amisulpride and Lithium: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Both drugs have been associated with QT prolongation, and amisulpride carries a dose-related risk of torsades de pointes. The combined risk is higher with electrolyte disturbance, bradycardia or renal impairment, which also raises lithium levels.
Cosa significa questa interazione in parole semplici
Amisulpride and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Perché avviene
Additive effects on cardiac repolarization leading to QT interval prolongation.
Cosa fare
Avoid the combination when possible. If used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor lithium levels and renal function.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Amisulpride e Lithium, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Lithium
- Lithium + Thioridazine Controindicata
- Lithium + Vandetanib Controindicata
- Aceclofenac + Lithium Maggiore
- Acemetacin + Lithium Maggiore
- Amlodipine-benazepril + Lithium Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Lithium Maggiore
Altre interazioni di Amisulpride
- Amiodarone + Amisulpride Controindicata
- Amisulpride + Arsenic trioxide Controindicata
- Amisulpride + Disopyramide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amisulpride + Droperidol Controindicata
- Amisulpride + Ibutilide Controindicata
Domande frequenti
Can I take Amisulpride with Lithium?
MediHelp rates the interaction as major. Amisulpride and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT prolongation, and amisulpride carries a dose-related risk of torsades de pointes. The combined risk is higher with electrolyte disturbance, bradycardia or renal impairment, which also raises lithium levels.
How serious is the interaction between Amisulpride and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor lithium levels and renal function.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
