Interazioni tra farmaci
Amisulpride + Arsenic trioxide
Gravità: Controindicata
Amisulpride and Arsenic trioxide: contraindicated interaction.
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Sintesi
Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
Cosa significa questa interazione in parole semplici
Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Arsenic trioxide belongs to Oncology.
Perché avviene
Additive prolongation of cardiac repolarization through effects on cardiac ion channels such as hERG.
Cosa fare
Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amisulpride
- Amiodarone + Amisulpride Controindicata
- Amisulpride + Disopyramide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amisulpride + Droperidol Controindicata
- Amisulpride + Ibutilide Controindicata
- Amisulpride + Pimozide Controindicata
Altre interazioni di Arsenic trioxide
- Amiodarone + Arsenic trioxide Controindicata
- Arsenic trioxide + Clomipramine Controindicata
- Arsenic trioxide + Dronedarone Controindicata
- Arsenic trioxide + Fluphenazine Controindicata
- Arsenic trioxide + Gemifloxacin Controindicata
- Arsenic trioxide + Hydroxychloroquine Controindicata
Domande frequenti
Can I take Amisulpride with Arsenic trioxide?
MediHelp rates the interaction as contraindicated. Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
How serious is the interaction between Amisulpride and Arsenic trioxide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Amisulpride page.
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