Interazioni tra farmaci
Amitriptyline + Azelastine
Gravità: Moderata
Amitriptyline and Azelastine: moderate interaction.
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Sintesi
Both drugs have sedative properties, and amitriptyline also has strong anticholinergic effects. Concurrent use may increase drowsiness, dizziness and impaired psychomotor performance.
Cosa significa questa interazione in parole semplici
Amitriptyline and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Azelastine belongs to Respiratory.
Perché avviene
Additive CNS depression via H1-receptor antagonism from both agents, plus anticholinergic effects of amitriptyline.
Cosa fare
Counsel on additive sedation and avoid driving until tolerance is established. Monitor elderly patients for confusion and falls.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Azelastine
- Azelastine + Calcium / magnesium / potassium / sodium oxybates Maggiore
- Azelastine + Methadone Maggiore
- Azelastine + Sodium oxybate Maggiore
- Alfentanil + Azelastine Moderata
- Alprazolam + Azelastine Moderata
- Amobarbital + Azelastine Moderata
Altre interazioni di Amitriptyline
- Amitriptyline + Isocarboxazid Controindicata
- Amitriptyline + Methylene blue Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amitriptyline + Pimozide Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amitriptyline + Safinamide Controindicata
Domande frequenti
Can I take Amitriptyline with Azelastine?
MediHelp rates the interaction as moderate. Amitriptyline and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative properties, and amitriptyline also has strong anticholinergic effects. Concurrent use may increase drowsiness, dizziness and impaired psychomotor performance.
How serious is the interaction between Amitriptyline and Azelastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving until tolerance is established. Monitor elderly patients for confusion and falls.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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