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Interazioni tra farmaci

Amitriptyline + Guanfacine

Gravità: Moderata

Amitriptyline and Guanfacine: moderate interaction.

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Sintesi

Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.

Cosa significa questa interazione in parole semplici

Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.

Livello di evidenza: Low

Perché avviene

Tricyclics may antagonize alpha-2 agonist action, and there is additive sedative and hypotensive pharmacodynamic effect.

Cosa fare

Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amitriptyline with Guanfacine?

MediHelp rates the interaction as moderate. Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.

How serious is the interaction between Amitriptyline and Guanfacine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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