Interazioni tra farmaci
Amitriptyline + Ziprasidone
Gravità: Controindicata
Amitriptyline and Ziprasidone: contraindicated interaction.
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Sintesi
Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.
Cosa significa questa interazione in parole semplici
Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Perché avviene
Additive QT interval prolongation.
Cosa fare
Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amitriptyline
- Amitriptyline + Isocarboxazid Controindicata
- Amitriptyline + Methylene blue Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amitriptyline + Pimozide Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amitriptyline + Safinamide Controindicata
Altre interazioni di Ziprasidone
- Amiodarone + Ziprasidone Controindicata
- Arsenic trioxide + Ziprasidone Controindicata
- Bedaquiline + Ziprasidone Controindicata
- Chloroquine + Ziprasidone Controindicata
- Citalopram + Ziprasidone Controindicata
- Clarithromycin + Ziprasidone Controindicata
Domande frequenti
Can I take Amitriptyline with Ziprasidone?
MediHelp rates the interaction as contraindicated. Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.
How serious is the interaction between Amitriptyline and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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