Interazioni tra farmaci
Amlodipine-atorvastatin + Cobicistat
Gravità: Maggiore
Amlodipine-atorvastatin and Cobicistat: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Cobicistat is a strong CYP3A4 inhibitor and also inhibits OATP1B1/1B3 and P-gp. It can substantially increase exposure to amlodipine and atorvastatin, raising risks of hypotension, edema and statin myopathy.
Cosa significa questa interazione in parole semplici
Amlodipine-atorvastatin and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Cobicistat belongs to Miscellaneous.
Perché avviene
Strong CYP3A4 and transporter inhibition by cobicistat reduces clearance of both amlodipine and atorvastatin.
Cosa fare
Use a lower amlodipine dose with blood pressure monitoring, and limit atorvastatin to the lowest effective dose per labeling, or choose a statin with less interaction such as rosuvastatin or pravastatin at low dose.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Amlodipine-atorvastatin e Cobicistat, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Amlodipine-atorvastatin
Altre interazioni di Cobicistat
- Alfuzosin + Cobicistat Controindicata
- Apalutamide + Cobicistat Controindicata
- Cobicistat + Colchicine Controindicata
- Cobicistat + Dronedarone Controindicata
- Cobicistat + Eletriptan Controindicata
- Cobicistat + Eplerenone Controindicata
Domande frequenti
Can I take Amlodipine-atorvastatin with Cobicistat?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and also inhibits OATP1B1/1B3 and P-gp. It can substantially increase exposure to amlodipine and atorvastatin, raising risks of hypotension, edema and statin myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Cobicistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower amlodipine dose with blood pressure monitoring, and limit atorvastatin to the lowest effective dose per labeling, or choose a statin with less interaction such as rosuvastatin or pravastatin at low dose.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
