Interazioni tra farmaci
Amlodipine-atorvastatin + Cyclosporine
Gravità: Maggiore
Amlodipine-atorvastatin and Cyclosporine: major interaction.
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Sintesi
Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
Cosa significa questa interazione in parole semplici
Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cyclosporine inhibits CYP3A4 and OATP1B1, and amlodipine may modestly raise cyclosporine levels through CYP3A4/P-gp effects.
Cosa fare
Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Amlodipine-atorvastatin
Domande frequenti
Can I take Amlodipine-atorvastatin with Cyclosporine?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
How serious is the interaction between Amlodipine-atorvastatin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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