Interazioni tra farmaci
Amlodipine-olmesartan-hydrochlorothiazide + Etodolac
Gravità: Maggiore
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac: major interaction.
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Sintesi
NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
Cosa significa questa interazione in parole semplici
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Perché avviene
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, antagonizing antihypertensive effects and impairing renal function.
Cosa fare
Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Controindicata
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
Altre interazioni di Etodolac
- Etodolac + Ketorolac Controindicata
- Etodolac + Ketorolac intranasal Controindicata
- Aceclofenac + Etodolac Maggiore
- Acemetacin + Etodolac Maggiore
- Acetylsalicylic acid + Etodolac Maggiore
- Alteplase + Etodolac Maggiore
Domande frequenti
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Etodolac?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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