Interazioni tra farmaci
Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide
Gravità: Controindicata
Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide: contraindicated interaction.
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Sintesi
Hydrochlorothiazide can raise dofetilide levels by reducing renal clearance and may cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
Cosa significa questa interazione in parole semplici
Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Perché avviene
Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.
Cosa fare
Avoid concomitant use and select a non-thiazide antihypertensive. If unavoidable, monitor QTc, potassium and magnesium closely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Controindicata
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Amiloride + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
Altre interazioni di Dofetilide
- Amiodarone + Dofetilide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Captopril-hydrochlorothiazide + Dofetilide Controindicata
- Chloroquine + Dofetilide Controindicata
Domande frequenti
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dofetilide?
MediHelp rates the interaction as contraindicated. Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels by reducing renal clearance and may cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a non-thiazide antihypertensive. If unavoidable, monitor QTc, potassium and magnesium closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Sparsentan, Acemetacin. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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