Interazioni tra farmaci
Amlodipine-perindopril + Sacubitril / valsartan
Gravità: Controindicata
Amlodipine-perindopril and Sacubitril / valsartan: contraindicated interaction.
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Sintesi
Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
Cosa significa questa interazione in parole semplici
Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive RAAS blockade, and neprilysin inhibition combined with ACE inhibition both impair bradykinin breakdown, raising angioedema risk.
Cosa fare
Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Controindicata
- Amlodipine-perindopril + Protein a column Controindicata
- Amifostine + Amlodipine-perindopril Maggiore
- Amiloride + Amlodipine-perindopril Maggiore
- Amlodipine-perindopril + Azilsartan Maggiore
- Amlodipine-perindopril + Candesartan Maggiore
Domande frequenti
Can I take Amlodipine-perindopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
How serious is the interaction between Amlodipine-perindopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Amifostine. The full list is on the Amlodipine-perindopril page.
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