Interazioni tra farmaci
Amphotericin b liposomal + Captopril-hydrochlorothiazide
Gravità: Moderata
Amphotericin b liposomal and Captopril-hydrochlorothiazide: moderate interaction.
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Sintesi
Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
Cosa significa questa interazione in parole semplici
Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Perché avviene
Additive renal potassium and magnesium wasting, with additive effects on renal hemodynamics and volume status.
Cosa fare
Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Controindicata
- Captopril-hydrochlorothiazide + Dofetilide Controindicata
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Controindicata
- Aceclofenac + Captopril-hydrochlorothiazide Maggiore
- Aldesleukin + Captopril-hydrochlorothiazide Maggiore
- Amifostine + Captopril-hydrochlorothiazide Maggiore
Altre interazioni di Amphotericin b liposomal
Domande frequenti
Can I take Amphotericin b liposomal with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
How serious is the interaction between Amphotericin b liposomal and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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