Drug interactions
Amphotericin b liposomal + Captopril-hydrochlorothiazide
Severity: Moderate
Amphotericin b liposomal and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
What this interaction means in plain words
Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium and magnesium wasting, with additive effects on renal hemodynamics and volume status.
What to do
Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Amphotericin b liposomal
Frequently asked questions
Can I take Amphotericin b liposomal with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
How serious is the interaction between Amphotericin b liposomal and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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