Interazioni tra farmaci
Amyl nitrite + Avanafil
Gravità: Controindicata
Amyl nitrite and Avanafil: contraindicated interaction.
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Sintesi
Both agents increase nitric oxide-cGMP signaling and vasodilation. Together they can cause profound, potentially fatal hypotension and syncope.
Cosa significa questa interazione in parole semplici
Amyl nitrite and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive vasodilation through nitrate-induced cGMP production and PDE5 inhibition preventing its breakdown.
Cosa fare
Do not use together; nitrates are contraindicated with PDE5 inhibitors. Avoid recreational nitrite inhalants for a prolonged period after avanafil and seek emergency care for severe hypotension.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Domande frequenti
Can I take Amyl nitrite with Avanafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents increase nitric oxide-cGMP signaling and vasodilation. Together they can cause profound, potentially fatal hypotension and syncope.
How serious is the interaction between Amyl nitrite and Avanafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; nitrates are contraindicated with PDE5 inhibitors. Avoid recreational nitrite inhalants for a prolonged period after avanafil and seek emergency care for severe hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Atazanavir, Clarithromycin, Conivaptan. The full list is on the Avanafil page.
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