Interazioni tra farmaci
Atazanavir + Avanafil
Gravità: Controindicata
Atazanavir and Avanafil: contraindicated interaction.
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Sintesi
Atazanavir inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual disturbances and priapism.
Cosa significa questa interazione in parole semplici
Atazanavir and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Avanafil belongs to Genitourinary.
Perché avviene
Inhibition of CYP3A4-mediated avanafil metabolism reduces its clearance.
Cosa fare
Do not use avanafil with atazanavir; choose another PDE5 inhibitor with dose limits or a non-PDE5 option for erectile dysfunction.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Avanafil
- Amyl nitrite + Avanafil Controindicata
- Avanafil + Clarithromycin Controindicata
- Avanafil + Conivaptan Controindicata
- Avanafil + Darunavir Controindicata
- Avanafil + Fosamprenavir Controindicata
- Avanafil + Indinavir Controindicata
Altre interazioni di Atazanavir
- Alfuzosin + Atazanavir Controindicata
- Atazanavir + Dronedarone Controindicata
- Atazanavir + Eletriptan Controindicata
- Atazanavir + Eplerenone Controindicata
- Atazanavir + Ergotamine Controindicata
- Atazanavir + Flibanserin Controindicata
Domande frequenti
Can I take Atazanavir with Avanafil?
MediHelp rates the interaction as contraindicated. Atazanavir and Avanafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual disturbances and priapism.
How serious is the interaction between Atazanavir and Avanafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use avanafil with atazanavir; choose another PDE5 inhibitor with dose limits or a non-PDE5 option for erectile dysfunction.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Clarithromycin, Conivaptan. The full list is on the Avanafil page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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