Interazioni tra farmaci
Anagrelide + Ivosidenib
Gravità: Maggiore
Anagrelide and Ivosidenib: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Ivosidenib is associated with QT prolongation, and anagrelide has a similar effect, so the combination may increase the risk of torsades de pointes. The legacy description of a QT decrease is not consistent with the known effects of either drug.
Cosa significa questa interazione in parole semplici
Anagrelide and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Perché avviene
Additive pharmacodynamic QT prolongation; ivosidenib is also a CYP3A4 inducer, which may lower anagrelide exposure.
Cosa fare
Avoid the combination if possible. If used together, monitor ECG and electrolytes regularly and reduce or stop therapy if QTc becomes markedly prolonged.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Anagrelide e Ivosidenib, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Anagrelide
- Anagrelide + Panobinostat Controindicata
- Anagrelide + Pimozide Controindicata
- Anagrelide + Thioridazine Controindicata
- Anagrelide + Vandetanib Controindicata
- Abrocitinib + Anagrelide Maggiore
- Alfuzosin + Anagrelide Maggiore
Altre interazioni di Ivosidenib
- Alfuzosin + Ivosidenib Maggiore
- Amiodarone + Ivosidenib Maggiore
- Amisulpride + Ivosidenib Maggiore
- Amitriptyline + Ivosidenib Maggiore
- Amobarbital + Ivosidenib Maggiore
- Apalutamide + Ivosidenib Maggiore
Domande frequenti
Can I take Anagrelide with Ivosidenib?
MediHelp rates the interaction as major. Anagrelide and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is associated with QT prolongation, and anagrelide has a similar effect, so the combination may increase the risk of torsades de pointes. The legacy description of a QT decrease is not consistent with the known effects of either drug.
How serious is the interaction between Anagrelide and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used together, monitor ECG and electrolytes regularly and reduce or stop therapy if QTc becomes markedly prolonged.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
