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Interazioni tra farmaci

Anagrelide + Panobinostat

Gravità: Controindicata

Anagrelide and Panobinostat: contraindicated interaction.

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Sintesi

Panobinostat markedly prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Adding anagrelide raises the risk of torsades de pointes and sudden death.

Cosa significa questa interazione in parole semplici

Anagrelide and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Anagrelide belongs to Cardiovascular; Panobinostat belongs to Oncology.

Livello di evidenza: Moderate

Perché avviene

Additive pharmacodynamic QT prolongation.

Cosa fare

Do not combine; select an alternative to anagrelide during panobinostat therapy. Monitor ECG and electrolytes per panobinostat labeling.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Anagrelide with Panobinostat?

MediHelp rates the interaction as contraindicated. Anagrelide and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat markedly prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Adding anagrelide raises the risk of torsades de pointes and sudden death.

How serious is the interaction between Anagrelide and Panobinostat?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative to anagrelide during panobinostat therapy. Monitor ECG and electrolytes per panobinostat labeling.

What other medicines interact with Anagrelide?

MediHelp also lists interactions of Anagrelide with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Anagrelide page.

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