Interazioni tra farmaci
Apomorphine + Palonosetron
Gravità: Controindicata
Apomorphine and Palonosetron: contraindicated interaction.
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Sintesi
Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
Cosa significa questa interazione in parole semplici
Apomorphine and Palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
Perché avviene
Mechanism is not established.
Cosa fare
Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Palonosetron
- Isocarboxazid + Palonosetron Maggiore
- Palonosetron + Phenelzine Maggiore
- Palonosetron + Tranylcypromine Maggiore
- Almotriptan + Palonosetron Moderata
- Amitriptyline + Palonosetron Moderata
- Amoxapine + Palonosetron Moderata
Altre interazioni di Apomorphine
- Alosetron + Apomorphine Controindicata
- Apomorphine + Cisapride Controindicata
- Apomorphine + Dolasetron Controindicata
- Apomorphine + Granisetron Controindicata
- Apomorphine + Netupitant-palonosetron Controindicata
- Apomorphine + Ondansetron Controindicata
Domande frequenti
Can I take Apomorphine with Palonosetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
How serious is the interaction between Apomorphine and Palonosetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Palonosetron page.
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