Interazioni tra farmaci
Apomorphine + Netupitant-palonosetron
Gravità: Controindicata
Apomorphine and Netupitant-palonosetron: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.
Cosa significa questa interazione in parole semplici
Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Perché avviene
The mechanism is not established; it is thought to involve a pharmacodynamic effect of 5-HT3 antagonism on apomorphine-related hypotension.
Cosa fare
Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Apomorphine e Netupitant-palonosetron, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Netupitant-palonosetron
- Flibanserin + Netupitant-palonosetron Controindicata
- Apalutamide + Netupitant-palonosetron Maggiore
- Avapritinib + Netupitant-palonosetron Maggiore
- Carbamazepine + Netupitant-palonosetron Maggiore
- Cobimetinib + Netupitant-palonosetron Maggiore
- Encorafenib + Netupitant-palonosetron Maggiore
Altre interazioni di Apomorphine
- Alosetron + Apomorphine Controindicata
- Apomorphine + Cisapride Controindicata
- Apomorphine + Dolasetron Controindicata
- Apomorphine + Granisetron Controindicata
- Apomorphine + Ondansetron Controindicata
- Apomorphine + Palonosetron Controindicata
Domande frequenti
Can I take Apomorphine with Netupitant-palonosetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.
How serious is the interaction between Apomorphine and Netupitant-palonosetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Flibanserin, Apalutamide, Avapritinib. The full list is on the Netupitant-palonosetron page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
