Interazioni tra farmaci
Apomorphine + Pimozide
Gravità: Controindicata
Apomorphine and Pimozide: contraindicated interaction.
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Sintesi
Pimozide blocks dopamine receptors and opposes the effect of apomorphine, a dopamine agonist. Both agents may also prolong the QT interval, raising arrhythmia risk.
Cosa significa questa interazione in parole semplici
Apomorphine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Perché avviene
Pharmacodynamic antagonism at dopamine D2 receptors plus additive QT prolongation.
Cosa fare
Avoid the combination. Use an alternative treatment for the indication that does not involve dopamine antagonism or QT prolongation.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Altre interazioni di Apomorphine
- Alosetron + Apomorphine Controindicata
- Apomorphine + Cisapride Controindicata
- Apomorphine + Dolasetron Controindicata
- Apomorphine + Granisetron Controindicata
- Apomorphine + Netupitant-palonosetron Controindicata
- Apomorphine + Ondansetron Controindicata
Domande frequenti
Can I take Apomorphine with Pimozide?
MediHelp rates the interaction as contraindicated. Apomorphine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide blocks dopamine receptors and opposes the effect of apomorphine, a dopamine agonist. Both agents may also prolong the QT interval, raising arrhythmia risk.
How serious is the interaction between Apomorphine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an alternative treatment for the indication that does not involve dopamine antagonism or QT prolongation.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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