Interazioni tra farmaci
Argatroban + Deferasirox
Gravità: Maggiore
Argatroban and Deferasirox: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
Cosa significa questa interazione in parole semplici
Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Perché avviene
Additive bleeding risk: mucosal injury from deferasirox plus anticoagulation from argatroban.
Cosa fare
Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Argatroban e Deferasirox, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Deferasirox
- Acetylsalicylic acid + Deferasirox Maggiore
- Alosetron + Deferasirox Maggiore
- Aluminum hydroxide + Deferasirox Maggiore
- Amikacin + Deferasirox Maggiore
- Aspirin / citric acid / sodium bicarbonate + Deferasirox Maggiore
- Aspirin + Deferasirox Maggiore
Altre interazioni di Argatroban
- Argatroban + Defibrotide Controindicata
- Argatroban + Ketorolac Controindicata
- Argatroban + Mifepristone Controindicata
- Abciximab + Argatroban Maggiore
- Acalabrutinib + Argatroban Maggiore
- Acetylsalicylic acid + Argatroban Maggiore
Domande frequenti
Can I take Argatroban with Deferasirox?
MediHelp rates the interaction as major. Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
How serious is the interaction between Argatroban and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
