Interazioni tra farmaci
Argatroban + Ketorolac
Gravità: Controindicata
Argatroban and Ketorolac: contraindicated interaction.
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Sintesi
Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.
Cosa significa questa interazione in parole semplici
Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Argatroban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Perché avviene
Additive hemostatic impairment from NSAID-mediated platelet inhibition and direct thrombin inhibition.
Cosa fare
Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ketorolac
- Aceclofenac + Ketorolac Controindicata
- Acemetacin + Ketorolac Controindicata
- Acetylsalicylic acid + Ketorolac Controindicata
- Apixaban + Ketorolac Controindicata
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Controindicata
- Aspirin rectal + Ketorolac Controindicata
Altre interazioni di Argatroban
- Argatroban + Defibrotide Controindicata
- Argatroban + Mifepristone Controindicata
- Abciximab + Argatroban Maggiore
- Acalabrutinib + Argatroban Maggiore
- Acetylsalicylic acid + Argatroban Maggiore
- Alteplase + Argatroban Maggiore
Domande frequenti
Can I take Argatroban with Ketorolac?
MediHelp rates the interaction as contraindicated. Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.
How serious is the interaction between Argatroban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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