Interazioni tra farmaci
Atazanavir + Bromocriptine
Gravità: Maggiore
Atazanavir and Bromocriptine: major interaction.
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Sintesi
Atazanavir inhibits CYP3A4, which metabolizes bromocriptine, so bromocriptine concentrations may rise. This can cause nausea, hypotension, headache and other dopaminergic toxicity.
Cosa significa questa interazione in parole semplici
Atazanavir and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Bromocriptine belongs to Central Nervous System.
Perché avviene
Inhibition of CYP3A4-mediated bromocriptine metabolism by atazanavir, which reduces clearance.
Cosa fare
Start bromocriptine at a low dose and titrate cautiously, or choose an alternative dopamine agonist. Monitor blood pressure and for dopaminergic adverse effects.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Domande frequenti
Can I take Atazanavir with Bromocriptine?
MediHelp rates the interaction as major. Atazanavir and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4, which metabolizes bromocriptine, so bromocriptine concentrations may rise. This can cause nausea, hypotension, headache and other dopaminergic toxicity.
How serious is the interaction between Atazanavir and Bromocriptine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start bromocriptine at a low dose and titrate cautiously, or choose an alternative dopamine agonist. Monitor blood pressure and for dopaminergic adverse effects.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Cobicistat, Darunavir. The full list is on the Bromocriptine page.
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