Interazioni tra farmaci
Atazanavir + Cariprazine
Gravità: Maggiore
Atazanavir and Cariprazine: major interaction.
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Sintesi
Atazanavir is a strong CYP3A4 inhibitor and can raise cariprazine and its active metabolites, which have long half-lives. This increases the risk of akathisia, extrapyramidal symptoms, sedation and metabolic effects.
Cosa significa questa interazione in parole semplici
Atazanavir and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Cariprazine belongs to Central Nervous System.
Perché avviene
Inhibition of CYP3A4, the main route of cariprazine metabolism.
Cosa fare
If starting cariprazine in a patient on atazanavir, use half the usual dose; if starting atazanavir in a patient on cariprazine, reduce the cariprazine dose by half (every other day if on 1.5 mg daily). Monitor for adverse effects for several weeks given the long half-life.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cariprazine
- Alfentanil + Cariprazine Maggiore
- Amisulpride + Cariprazine Maggiore
- Amobarbital + Cariprazine Maggiore
- Apalutamide + Cariprazine Maggiore
- Benzhydrocodone / acetaminophen + Cariprazine Maggiore
- Brexanolone + Cariprazine Maggiore
Altre interazioni di Atazanavir
- Alfuzosin + Atazanavir Controindicata
- Atazanavir + Avanafil Controindicata
- Atazanavir + Dronedarone Controindicata
- Atazanavir + Eletriptan Controindicata
- Atazanavir + Eplerenone Controindicata
- Atazanavir + Ergotamine Controindicata
Domande frequenti
Can I take Atazanavir with Cariprazine?
MediHelp rates the interaction as major. Atazanavir and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can raise cariprazine and its active metabolites, which have long half-lives. This increases the risk of akathisia, extrapyramidal symptoms, sedation and metabolic effects.
How serious is the interaction between Atazanavir and Cariprazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If starting cariprazine in a patient on atazanavir, use half the usual dose; if starting atazanavir in a patient on cariprazine, reduce the cariprazine dose by half (every other day if on 1.5 mg daily). Monitor for adverse effects for several weeks given the long half-life.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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