Interazioni tra farmaci
Atidarsagene autotemcel + Tenofovir disoproxil
Gravità: Maggiore
Atidarsagene autotemcel and Tenofovir disoproxil: major interaction.
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Sintesi
Antiretrovirals can interfere with the manufacture of gene-modified autologous cell products by inhibiting lentiviral transduction. Tenofovir taken before and during cell collection may reduce the quality of the product.
Cosa significa questa interazione in parole semplici
Atidarsagene autotemcel and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Antiretroviral inhibition of lentiviral vector transduction of harvested cells during manufacturing.
Cosa fare
Stop antiretrovirals for at least one month, or longer for long-acting agents, before cell mobilization and until apheresis is complete. Coordinate with the HIV specialist on management of the interruption.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Atidarsagene autotemcel
Domande frequenti
Can I take Atidarsagene autotemcel with Tenofovir disoproxil?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals can interfere with the manufacture of gene-modified autologous cell products by inhibiting lentiviral transduction. Tenofovir taken before and during cell collection may reduce the quality of the product.
How serious is the interaction between Atidarsagene autotemcel and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop antiretrovirals for at least one month, or longer for long-acting agents, before cell mobilization and until apheresis is complete. Coordinate with the HIV specialist on management of the interruption.
What other medicines interact with Atidarsagene autotemcel?
MediHelp also lists interactions of Atidarsagene autotemcel with, for example, Didanosine, Dolutegravir, Efavirenz. The full list is on the Atidarsagene autotemcel page.
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