Interazioni tra farmaci
Atorvastatin + Cyclosporine
Gravità: Maggiore
Atorvastatin and Cyclosporine: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Cyclosporine markedly increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin labeling advises avoiding the combination. Transplant recipients, older patients and those with renal impairment are at particular risk.
Cosa significa questa interazione in parole semplici
Atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cyclosporine inhibits OATP1B1 hepatic uptake and also inhibits CYP3A4 and P-gp, reducing atorvastatin clearance and increasing systemic levels.
Cosa fare
Avoid concomitant use per atorvastatin labeling; consider fluvastatin, pravastatin or rosuvastatin at limited doses as recommended in their labels. If a statin is required, use the lowest effective dose and monitor for muscle symptoms, with CK measurement if they appear.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Atorvastatin
- Atorvastatin + Tipranavir Controindicata
- Atazanavir + Atorvastatin Maggiore
- Atorvastatin + Clarithromycin Maggiore
- Atorvastatin + Cobicistat Maggiore
- Atorvastatin + Cyclosporin Maggiore
- Atorvastatin + Danazol Maggiore
Domande frequenti
Can I take Atorvastatin with Cyclosporine?
MediHelp rates the interaction as major. Atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine markedly increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin labeling advises avoiding the combination. Transplant recipients, older patients and those with renal impairment are at particular risk.
How serious is the interaction between Atorvastatin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use per atorvastatin labeling; consider fluvastatin, pravastatin or rosuvastatin at limited doses as recommended in their labels. If a statin is required, use the lowest effective dose and monitor for muscle symptoms, with CK measurement if they appear.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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