Interazioni tra farmaci
Atorvastatin + Vitamin b3
Gravità: Moderata
Atorvastatin and Vitamin b3: moderate interaction.
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Sintesi
Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.
Cosa significa questa interazione in parole semplici
Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Vitamin b3 belongs to Gastrointestinal Tract.
Perché avviene
Additive myotoxicity, with a possible minor pharmacokinetic contribution; the mechanism is not fully established.
Cosa fare
Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Vitamin b3
- Lovastatin + Vitamin b3 Maggiore
- Simvastatin + Vitamin b3 Maggiore
- Cholestyramine + Vitamin b3 Moderata
- Colestipol + Vitamin b3 Moderata
- Fluvastatin + Vitamin b3 Moderata
- Insulin aspart protamine / insulin aspart + Vitamin b3 Moderata
Altre interazioni di Atorvastatin
- Atorvastatin + Tipranavir Controindicata
- Atazanavir + Atorvastatin Maggiore
- Atorvastatin + Clarithromycin Maggiore
- Atorvastatin + Cobicistat Maggiore
- Atorvastatin + Cyclosporin Maggiore
- Atorvastatin + Cyclosporine Maggiore
Domande frequenti
Can I take Atorvastatin with Vitamin b3?
MediHelp rates the interaction as moderate. Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.
How serious is the interaction between Atorvastatin and Vitamin b3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Cholestyramine. The full list is on the Vitamin b3 page.
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