Interazioni tra farmaci
Bcg vaccine live + Cyclosporin
Gravità: Controindicata
Bcg vaccine live and Cyclosporin: contraindicated interaction.
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Sintesi
BCG is a live attenuated vaccine, and in a patient on cyclosporin the organism may replicate uncontrolled and cause disseminated BCG infection. The immunosuppression may also prevent an adequate protective response.
Cosa significa questa interazione in parole semplici
Bcg vaccine live and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Calcineurin-inhibitor immunosuppression impairs cell-mediated immunity needed to control the live attenuated organism and to mount a vaccine response.
Cosa fare
Do not give BCG to patients taking cyclosporin. Defer live vaccination until immunosuppressant therapy has been stopped for an appropriate interval, generally at least 3 months, as advised by a specialist.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
- Cyclosporin + Elagolix Controindicata
Domande frequenti
Can I take Bcg vaccine live with Cyclosporin?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG is a live attenuated vaccine, and in a patient on cyclosporin the organism may replicate uncontrolled and cause disseminated BCG infection. The immunosuppression may also prevent an adequate protective response.
How serious is the interaction between Bcg vaccine live and Cyclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG to patients taking cyclosporin. Defer live vaccination until immunosuppressant therapy has been stopped for an appropriate interval, generally at least 3 months, as advised by a specialist.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bosentan. The full list is on the Cyclosporin page.
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