Interazioni tra farmaci
Belladonna and opium + Butorphanol
Gravità: Maggiore
Belladonna and opium and Butorphanol: major interaction.
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Sintesi
Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
Cosa significa questa interazione in parole semplici
Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive opioid CNS depression combined with partial mu antagonism by butorphanol at receptors occupied by morphine from opium.
Cosa fare
Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Butorphanol
- Butorphanol + Olanzapine / samidorphan Controindicata
- Butorphanol + Sodium oxybate Controindicata
- Alfentanil + Butorphanol Maggiore
- Alprazolam + Butorphanol Maggiore
- Alvimopan + Butorphanol Maggiore
- Amobarbital + Butorphanol Maggiore
Domande frequenti
Can I take Belladonna and opium with Butorphanol?
MediHelp rates the interaction as major. Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
How serious is the interaction between Belladonna and opium and Butorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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