Interazioni tra farmaci
Butorphanol + Olanzapine / samidorphan
Gravità: Controindicata
Butorphanol and Olanzapine / samidorphan: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Samidorphan is an opioid antagonist that blocks butorphanol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
Cosa significa questa interazione in parole semplici
Butorphanol and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Samidorphan antagonizes opioid receptors, opposing the effect of butorphanol.
Cosa fare
Avoid the combination; follow the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesics during treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Butorphanol
- Butorphanol + Sodium oxybate Controindicata
- Alfentanil + Butorphanol Maggiore
- Alprazolam + Butorphanol Maggiore
- Alvimopan + Butorphanol Maggiore
- Amobarbital + Butorphanol Maggiore
- Belladonna and opium + Butorphanol Maggiore
Domande frequenti
Can I take Butorphanol with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Butorphanol and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks butorphanol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
How serious is the interaction between Butorphanol and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; follow the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesics during treatment.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Butorphanol page.
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