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Interazioni tra farmaci

Bevacizumab + Doxorubicin liposomal

Gravità: Moderata

Bevacizumab and Doxorubicin liposomal: moderate interaction.

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Sintesi

Both agents have been associated with cardiac dysfunction, and bevacizumab can cause hypertension and heart failure. Together the risk of cardiomyopathy may be increased.

Cosa significa questa interazione in parole semplici

Bevacizumab and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Livello di evidenza: Moderate

Perché avviene

Additive cardiotoxicity from anthracycline myocardial injury and bevacizumab-related hypertension and cardiac dysfunction.

Cosa fare

Assess left ventricular ejection fraction before and during treatment and monitor blood pressure; stop or modify therapy if heart failure develops.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Bevacizumab with Doxorubicin liposomal?

MediHelp rates the interaction as moderate. Bevacizumab and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with cardiac dysfunction, and bevacizumab can cause hypertension and heart failure. Together the risk of cardiomyopathy may be increased.

How serious is the interaction between Bevacizumab and Doxorubicin liposomal?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular ejection fraction before and during treatment and monitor blood pressure; stop or modify therapy if heart failure develops.

What other medicines interact with Bevacizumab?

MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.

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