Interazioni tra farmaci
Bortezomib + Idelalisib
Gravità: Maggiore
Bortezomib and Idelalisib: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
Cosa significa questa interazione in parole semplici
Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Idelalisib belongs to Oncology.
Perché avviene
Idelalisib inhibits CYP3A4, reducing bortezomib clearance.
Cosa fare
Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Bortezomib
- Apalutamide + Bortezomib Maggiore
- Bortezomib + Carbamazepine Maggiore
- Bortezomib + Etrasimod Maggiore
- Bortezomib + Fosphenytoin Maggiore
- Bortezomib + Lonafarnib Maggiore
- Bortezomib + Mitotane Maggiore
Altre interazioni di Idelalisib
- Alfuzosin + Idelalisib Controindicata
- Cisapride + Idelalisib Controindicata
- Dihydroergotamine + Idelalisib Controindicata
- Dronedarone + Idelalisib Controindicata
- Eletriptan + Idelalisib Controindicata
- Eplerenone + Idelalisib Controindicata
Domande frequenti
Can I take Bortezomib with Idelalisib?
MediHelp rates the interaction as major. Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
How serious is the interaction between Bortezomib and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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