Interazioni tra farmaci
Dihydroergotamine + Idelalisib
Gravità: Controindicata
Dihydroergotamine and Idelalisib: contraindicated interaction.
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Sintesi
Idelalisib may greatly increase dihydroergotamine levels, raising the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Idelalisib belongs to Oncology.
Perché avviene
Strong CYP3A inhibition by idelalisib's metabolite reduces dihydroergotamine clearance.
Cosa fare
Avoid the combination and use another migraine therapy during idelalisib treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Idelalisib
- Alfuzosin + Idelalisib Controindicata
- Cisapride + Idelalisib Controindicata
- Dronedarone + Idelalisib Controindicata
- Eletriptan + Idelalisib Controindicata
- Eplerenone + Idelalisib Controindicata
- Ergotamine + Idelalisib Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Idelalisib?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib may greatly increase dihydroergotamine levels, raising the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use another migraine therapy during idelalisib treatment.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Cisapride, Dronedarone. The full list is on the Idelalisib page.
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