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Brimonidine + Tranylcypromine

Gravità: Controindicata

Brimonidine and Tranylcypromine: contraindicated interaction.

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Sintesi

Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.

Cosa significa questa interazione in parole semplici

Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Brimonidine belongs to Miscellaneous; Tranylcypromine belongs to Central Nervous System.

Livello di evidenza: Low

Perché avviene

Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects

Cosa fare

Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Brimonidine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.

How serious is the interaction between Brimonidine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.

What other medicines interact with Tranylcypromine?

MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.

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