Interazioni tra farmaci
Brimonidine + Linezolid
Gravità: Controindicata
Brimonidine and Linezolid: contraindicated interaction.
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Sintesi
Brimonidine labelling forbids use with MAO inhibitors, and linezolid is an oxazolidinone antibiotic with weak, reversible MAO-inhibiting activity. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
Cosa significa questa interazione in parole semplici
Brimonidine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Linezolid belongs to Anti Bacterial.
Perché avviene
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
Cosa fare
Avoid brimonidine in patients taking linezolid; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Linezolid
- Amoxapine + Linezolid Controindicata
- Atomoxetine + Linezolid Controindicata
- Benzphetamine + Linezolid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion + Linezolid Controindicata
- Buspirone + Linezolid Controindicata
Altre interazioni di Brimonidine
- Brimonidine + Isocarboxazid Controindicata
- Brimonidine + Phenelzine Controindicata
- Brimonidine + Procarbazine Controindicata
- Brimonidine + Rasagiline Controindicata
- Brimonidine + Selegiline Controindicata
- Brimonidine + Tranylcypromine Controindicata
Domande frequenti
Can I take Brimonidine with Linezolid?
MediHelp rates the interaction as contraindicated. Brimonidine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and linezolid is an oxazolidinone antibiotic with weak, reversible MAO-inhibiting activity. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking linezolid; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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