Interazioni tra farmaci
Buprenorphine long-acting + Chlordiazepoxide-clidinium
Gravità: Maggiore
Buprenorphine long-acting and Chlordiazepoxide-clidinium: major interaction.
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Sintesi
Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
Cosa significa questa interazione in parole semplici
Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
Cosa fare
Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Maggiore
- Alprazolam + Chlordiazepoxide-clidinium Maggiore
- Amobarbital + Chlordiazepoxide-clidinium Maggiore
- Belladonna and opium + Chlordiazepoxide-clidinium Maggiore
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Maggiore
- Brexanolone + Chlordiazepoxide-clidinium Maggiore
Domande frequenti
Can I take Buprenorphine long-acting with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
How serious is the interaction between Buprenorphine long-acting and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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